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Sucralose: An Excellent Safety Profile
Sucralose, the sweetening ingredient in SPLENDA® Sweetener Products, is one of the most rigorously tested food additives and has been the subject of more than 110 scientific studies to establish its safety.1
These studies have concluded that sucralose is suitable for use by everyone.
Conclusions that are based on the full body of sucralose safety studies include the following:
- No known side effects
- No toxicity, even in test diets simulating the sweetness of 40+ pounds of sugar per day for life
- No bioaccumulation
- No carcinogenicity
- No genotoxicity
- No effects on fetal or neonatal development
- No neurotoxicity
- No cariogenicity
- No effect on carbohydrate metabolism (sucralose is not hydrolyzed or broken down for energy)
- No calories or carbohydrates
- No effect on short- or long-term glucose control or on serum insulin levels
Who can use sucralose?
Sucralose (SPLENDA® Brand Sweetener) is suitable for everyone, including:
People with diabetes
Sucralose is not recognized by the body as a carbohydrate, is not metabolized for energy, and provides no calories.
Clinical trials among patients with diabetes and among normal controls have shown that sucralose has no effect on insulin levels, fasting or postprandial blood glucose levels, and long-term blood glucose control (hemoglobin 1c).1-3 A multicentre study demonstrated that daily sucralose consumption of triple the maximum projected daily intake for 3 months had no effect on glucose homeostasis in patients with type 2 diabetes.3
Women who are pregnant or nursing
Sucralose can be used safely during pregnancy and by nursing mothers. Studies in animal models showed that sucralose is not actively transported across the placental barrier or from the mammary gland into breast milk.
While mothers typically have higher nutritional needs during pregnancy and nursing, sucralose may help women avoid excess calorie intake from sugar during these times.
Over the last 25 years, obesity rates among children and youth in Canada have nearly tripled.4 Substituting sugar with SPLENDA® Sweetener Products is an excellent way to help children reduce their added sugar and calorie intake.
Data show that SPLENDA® Brand Sweetener (sucralose) can be used safely by all populations, including people with diabetes, women who are pregnant or nursing, and children.
1. Grotz VL, Munroe IC. An Overview of the Safety of Sucralose. Regulatory Toxicology and Pharmocology. 2009;55:1-5.
2. Mezitis NHE, Maggio CA, Koch P, et al. Glycemic effect of a single high oral dose of the novel sweetener sucralose in patients with diabetes. Diabetes Care. 1996;19(9):1004-1005.
3. Grotz VL, Henry RR, McGill JB, et al. Lack of effect of sucralose on glucose homeostasis in subjects with type 2 diabetes. J Am Diet Assoc. 2003;103(12):1607-1612.
4. Childhood Obesity. Government of Canada Healthy Canadians website.http://healthycanadians.gc.ca/kids/childhood-obesity/
Published November 19, 2010. Accessed January 19, 2011.